Missouri is a state in the Midwestern region of the United States.[6] Ranking 21st in land area, it is bordered by eight states (tied for the most with Tennessee): Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. The Missouri River, after which the state is named, flows through the center into the Mississippi River, which makes up the eastern border. With more than six million residents, it is the 19th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Springfield, and Columbia; the capital is Jefferson City.

Humans have inhabited what is now Missouri for at least 12,000 years. The Mississippian culture, which emerged at least in the ninth century, built cities and mounds before declining in the 14th century. When European explorers arrived in the 17th century, they encountered the Osage and Missouria nations. The French incorporated the territory into Louisiana, founding Ste. Genevieve in 1735 and St. Louis in 1764. After a brief period of Spanish rule, the United States acquired Missouri as part of the Louisiana Purchase in 1803. Americans from the Upland South rushed into the new Missouri Territory. Missouri was admitted as a slave state as part of the Missouri Compromise of 1820. Many from Virginia, Kentucky, and Tennessee settled in the Boonslick area of Mid-Missouri. Soon after, heavy German immigration formed the Missouri Rhineland.